High-Performance Computing at the NIH
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The NIH HPC group plans, manages and supports high-performance computing systems specifically for the intramural NIH community. These systems include Biowulf, an 20,000+ processor Linux cluster; Helix, an interactive system for short jobs, Sciware, a set of applications for desktops, and Helixweb, which provides a number of web-based scientific tools. We provide access to a wide range of computational applications for genomics, molecular and structural biology, mathematical and graphical analysis, image analysis, and other scientific fields.

Recent Papers that used Biowulf & HPC Resources

thumbnail image from paper Cryo-EM Structures Reveal Mechanism and Inhibition of DNA Targeting by a CRISPR-Cas Surveillance Complex
Guo, TW; Bartesaghi, A; Yang, H et al.
Cell , DOI://10.1016/j.cell.2017.09.006 (2017)

The FUT2 secretor variant p.Trp154Ter influences serum vitamin B12 concentration via holo-haptocorrin, but not holo-transcobalamin, and is associated with haptocorrin glycosylation
Velkova, A; Diaz, JEL; Pangilinan, F et al.
Hum. Mol. Genet. , DOI://10.1093/hmg/ddx369 (2017)

thumbnail image from paper A functional connectivity-based neuromarker of sustained attention generalizes to predict recall in a reading task
Jangraw, DC; Gonzalez-Castillo, J; Handwerker, DA et al.
Neuroimage , DOI://10.1016/j.neuroimage.2017.10.019 (2017)

thumbnail image from paper MicroRNA Signature of Cigarette Smoking and Evidence for a Putative Causal Role of MicroRNAs in Smoking-Related Inflammation and Target Organ Damage
Willinger, CM; Rong, J; Tanriverdi, K et al.
Circ Cardiovasc Genet , DOI://10.1161/CIRCGENETICS.116.001678 (2017)

thumbnail image from paper Rapid Nanopore Sequencing of Plasmids and Resistance Gene Detection in Clinical Isolates
Lemon, JK; Khil, PP; Frank, KM; Dekker, JP;
J. Clin. Microbiol. , DOI://10.1128/JCM.01069-17 (2017)

thumbnail image from paper Molecular Dynamics Simulations of Ceramide and Ceramide-Phosphatidylcholine Bilayers
Wang, E; Klauda, JB;
J Phys Chem B , DOI://10.1021/acs.jpcb.7b08967 (2017)

thumbnail image from paper Structure of FUS Protein Fibrils and Its Relevance to Self-Assembly and Phase Separation of Low-Complexity Domains
Murray, DT; Kato, M; Lin, Y et al.
Cell , DOI://10.1016/j.cell.2017.08.048 (2017)