High-Performance Computing at the NIH

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ProbABEL on Helix

ProbABEL is a package for genome-wide association analysis of imputed data developed by Yurii Aulchenko etc. Currently, ProbABEL implements linear, logistic regression, and Cox proportional hazards models. The corresponding analysis programs are called palinear, palogist, and pacoxph.

 

The environment variable(s) need to be set properly first. The easiest way to do this is by using the modules commands as in the example below.

$ module avail probabel
-------------------- /usr/local/Modules/3.2.9/modulefiles ----------------------
probabel/0.2.0

$ module load probabel

$ module list
Currently Loaded Modulefiles:
1) probabel/0.2.0 $ module unload probabel $ module load probabel/0.2.0 $ module show probabel ------------------------------------------------------------------- /usr/local/Modules/3.2.9/modulefiles/probabel/0.2.0: module-whatis Sets up probabel 0.2.0 prepend-path PATH /usr/local/apps/probabel/0.2.0/bin -----------------------------------------------------------------

Sample Session on Helix

ProbABEL sample files can be copied from:

/usr/local/apps/probabel/current/examples

There are several scripts containing commands (files ending in .sh) under this directory. User can modify and run accordingly. The main script is called example_all.sh which in turn calls other script files.

% sh example_all.sh

Documentation

http://helix.nih.gov/Applications/probabel.pdf